Annotation of rs104894540

Allele G is associated with increased dose of warfarin as compared to allele A.

Allele G (Val45Ala) is associated with severe warfarin resistance, may require a higher dose (INR never reached).

From Publication

Oral anticoagulants: Pharmacogenetics Relationship between genetic and non-genetic factors. Blood reviews. 2008. D'Andrea Giovanna et al.
PMID:18234403(opens in new window) DOI:10.1016/j.blre.2007.11.004(opens in new window)

Gene

VKORC1

Variant

rs104894540

Phenotype Category

Dosage

Association Significance

The study does not report on the significance of this association

PharmGKB ID

981239514

Score
More info on scoring

0

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

  1. Clinical Annotation for rs104894540 (VKORC1); warfarin (level 3 Dosage)

Study Parameters

Not Available

Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

History

No history available.