Annotation of rs9923231

Genotype TT is associated with decreased dose of warfarin as compared to genotypes CC + CT.

in patients early after heart valve replacement surgery.

From Publication

Impact of genetic and clinical factors on warfarin therapy in patients early after heart valve replacement surgery. European journal of clinical pharmacology. 2019. Li Boxia et al.
PMID:31444512(opens in new window) DOI:10.1007/s00228-019-02747-5(opens in new window)

Gene

VKORC1

Variant

rs9923231

Phenotype Category

Dosage

Association Significance

The study reports this association is significant

PharmGKB ID

1450935595

Score
More info on scoring

2.75

Evidence for Clinical Annotations

This annotation has not been used as evidence for any clinical annotations.

Study Parameters

Study type

cohort

Study size

289

Association p-value

< 0.0001

Biogeographical group
More info on groups

East Asian

Population description

Study Cohort: Chinese patients undergoing heart valve replacement.

Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

History

No history available.