Annotation of rs9923231

Allele T is associated with decreased dose of warfarin as compared to allele C.

Please note: alleles have been complemented to the + chromosomal strand.

From Publication

Warfarin Dose Model for the Prediction of Stable Maintenance Dose in Indian Patients. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. 2018. Gaikwad Tejasvita et al.
PMID:28049362(opens in new window) PMCID:PMC6714673(opens in new window) DOI:10.1177/1076029616683046(opens in new window)

Gene

VKORC1

Variant

rs9923231

Phenotype Category

Dosage, Other

Association Significance

The study reports this association is significant

PharmGKB ID

1449192273

Score
More info on scoring

3.25

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    1.

    Study type

    cohort

    Study size

    300

    Association p-value

    = 0.001

    Biogeographical group
    More info on groups

    Central/South Asian

    Population description

    men; women

    Drug: dose (mg/day) warfarin: CC 5.55, CT 3.68, TT 2.12

    2.

    Study type

    cohort

    Study size

    300

    Association p-value

    = 0.001

    Biogeographical group
    More info on groups

    Central/South Asian

    Population description

    men; women

    Drug: dose; estimate -0.406740, SE 0.030869, partial R sq. 0.23

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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