Annotation of rs9934438

Genotypes AA + AG are associated with decreased dose of acenocoumarol as compared to genotype GG.

The acenocoumarol dosage in mg/week had to be significantly titrated downward in association with an increasing number of VKORC1 A-alleles (-5.1, 95% CI -5.5 to -4.7, Pvalue for trend <0.0001).

From Publication

Genotypes associated with reduced activity of VKORC1 and CYP2C9 and their modification of acenocoumarol anticoagulation during the initial treatment period. Clinical pharmacology and therapeutics. 2009. Teichert M et al.
PMID:19225451(opens in new window) DOI:10.1038/clpt.2008.294(opens in new window)

Gene

VKORC1

Variant

rs9934438

Phenotype Category

Dosage

Association Significance

The study reports this association is significant

PharmGKB ID

1444706973

Score
More info on scoring

3

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    1525

    Association p-value

    < 0.0001

    Biogeographical group
    More info on groups

    European

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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