Annotation of rs7196161

Allele A is not associated with increased dose of acenocoumarol as compared to allele G.

There were significant differences in mean daily dose of acenocoumarol between individuals of different genotypes GG (N=4), AG (N=46), and AA (N=167). The mean daily dose of the GG genotype was 1.3 (+/-0.5) mg, the AG genotype was 2.1 (+/-1.0) mg, and the AA genotype was 4.2 (+/-2.3) mg. The A allele was significant in univariate analysis (B=-0.285; SE=0.035; adj R sq.=0.230; P<0.00) but did not remain significant in the multiple linear regression analysis.

Gene

VKORC1

Variant

rs7196161

Phenotype Category

Dosage

Association Significance

The study reports this association is not significant

PharmGKB ID

1444699635

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    217

    Association p-value

    > 0.05

    Allele frequency

    A=0.876; G=0.124

    Biogeographical group
    More info on groups

    Central/South Asian

    Population description

    men; women

    Drug: acenocoumarol for at least 3 months with INR of 2-3.5; digoxin, furosemide, penicillin and verapamil (co-prescribed).

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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