Annotation of rs7196161
Allele A is not associated with increased dose of acenocoumarol as compared to allele G.
There were significant differences in mean daily dose of acenocoumarol between individuals of different genotypes GG (N=4), AG (N=46), and AA (N=167). The mean daily dose of the GG genotype was 1.3 (+/-0.5) mg, the AG genotype was 2.1 (+/-1.0) mg, and the AA genotype was 4.2 (+/-2.3) mg. The A allele was significant in univariate analysis (B=-0.285; SE=0.035; adj R sq.=0.230; P<0.00) but did not remain significant in the multiple linear regression analysis.
From Publication
Gene
Variant
Phenotype Category
Association Significance
PharmGKB ID
Score More info on scoring
Evidence for Clinical Annotations
This annotation has been used as evidence for the following clinical annotations.
Study Parameters
Study type
Study size
Association p-value
Allele frequency
Biogeographical group More info on groups
Population description
Drug: acenocoumarol for at least 3 months with INR of 2-3.5; digoxin, furosemide, penicillin and verapamil (co-prescribed).
Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.