Annotation of rs9923231

Genotype TT is associated with dose of fluindione in children as compared to genotype CC.

From Publication

Vitamin K antagonists in children with heart disease: height and VKORC1 genotype are the main determinants of the warfarin dose requirement. Blood. 2012. Moreau Caroline et al.
PMID:22130800(opens in new window) PMCID:PMC3384479(opens in new window) DOI:10.1182/blood-2011-07-365502(opens in new window)

Gene

VKORC1

Variant

rs9923231

Phenotype Category

Metabolism/PK

Association Significance

The study reports this association is significant

Specialty Population

PediatricLearn more about pediatric tags(opens in new window)

PharmGKB ID

982047927

Score
More info on scoring

1

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    35

    Association p-value

    = 0.0363

    Allele frequency

    G=0.66

    Biogeographical group
    More info on groups

    European

    Population description

    children (pediatrics)

    Age Group: Mean age = 11 (3-18 years)

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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