Annotation of rs1042711

Allele T is not associated with response to atenolol in people with Essential hypertension.

Either alone as a SNP or in combination with rs1042713 allele A and rs1042714 allele C as a haplotype. Neither this SNP nor any haplotype combination (haplotypes TGC, CGG, TGG, TAG and CAG were also present in the population) predicted systolic blood pressure or diastolic blood pressure response to atenolol after 4 or 8 weeks of treatment, either in the combined cohort or after sex stratification (data was not shown).

From Publication

Haplotypes of the adrenergic system predict the blood pressure response to beta-blockers in women with essential hypertension. Pharmacogenomics. 2010. Filigheddu Fabiana et al.
PMID:20235788(opens in new window) DOI:10.2217/pgs.09.158(opens in new window)

Gene

ADRB2

Variant

rs1042711

Phenotype Category

Efficacy

Association Significance

The study reports this association is not significant

PharmGKB ID

982044884

Score
More info on scoring

-1.75

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    340

    Biogeographical group
    More info on groups

    European

    Population description

    Study Cohort: p > 0.05

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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