Annotation of rs12233719

Allele T is associated with decreased clearance of carvedilol in people with Heart Diseases as compared to allele G.

When allele T is in combination with rs28365063 G allele, the combination of which is defined as UGT2B7*3 by the UGT Nomenclature Committee. As compared to the G allele combined with rs28365063 A allele (wild-type, or UGT2B7*1). In other words, UGT2B7*3 is associated with decreased oral clearance (CL/F) of carvedilol as compared to UGT2B7*1.

From Publication

Evaluation of effects of polymorphism for metabolic enzymes on pharmacokinetics of carvedilol by population pharmacokinetic analysis. Biological & pharmaceutical bulletin. 2007. Takekuma Yoh et al.
PMID:17329852(opens in new window) DOI:10.1248/bpb.30.537(opens in new window)

Gene

UGT2B7

Variant

rs12233719

Phenotype Category

Metabolism/PK

Association Significance

The study reports this association is significant

PharmGKB ID

982044299

Score
More info on scoring

1.5

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    41

    Association p-value

    < 0.001

    Biogeographical group
    More info on groups

    East Asian

    Population description

    men

    Gender: 81% male. Disease: chronic heart failure or angina pectoris.

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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