Annotation of rs11887534

Genotypes CC + CG are associated with increased response to atorvastatin in people with Hypercholesterolemia as compared to genotype GG.

as measured by larger reductions in LDL cholesterol in patients with the C allele. Variant described as D19H. The effect of the rs11887534 C allele was greater in patients with the rs3808607 TT genotype and became smaller with increased number of rs3808607 G alleles.

From Publication

Interactions between common genetic polymorphisms in ABCG5/G8 and CYP7A1 on LDL cholesterol-lowering response to atorvastatin. Atherosclerosis. 2004. Kajinami Kouji et al.
PMID:15262185(opens in new window) DOI:10.1016/j.atherosclerosis.2004.03.015(opens in new window)

Gene

ABCG8

Variant

rs11887534

Phenotype Category

Efficacy

Association Significance

The study reports this association is significant

PharmGKB ID

982043865

Score
More info on scoring

2.25

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    337

    Association p-value

    = 0.043

    Population description

    Study Cohort: P value after adjustment for age and pretreatment LDL cholesterol.

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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