Annotation of rs7079

Genotype TT is associated with increased response to benazepril in people with Hypertension as compared to genotypes GG + GT.

Patients with the TT genotype had a greater decrease in diastolic blood pressure between baseline and 3 years of treatment, compared to those with the GT or GG genotypes. Genotypes were analyzed in an exploratory group (n=733), a confirmatory group (n=714) and for the total population (n=1447). A significant result for systolic blood pressure was seen in the total population. Please note alleles have been complemented to the plus chromosomal strand.

Gene

AGT

Variant

rs7079

Phenotype Category

Efficacy

Association Significance

The study reports this association is significant

PharmGKB ID

982037006

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    1.

    Study type

    cohort

    Study size

    1447

    Association p-value

    = 0.001

    Allele frequency

    G=0.86

    Biogeographical group
    More info on groups

    East Asian

    Population description

    Study Cohort: Chinese Community-Based Comprehensive Prevention and Control of Hypertension project. p-value for the total population when considering diastolic blood pressure.

    2.

    Study type

    cohort

    Study size

    714

    Association p-value

    = 0.017

    Allele frequency

    G=0.87

    Biogeographical group
    More info on groups

    East Asian

    Population description

    Study Cohort: Chinese Community-Based Comprehensive Prevention and Control of Hypertension project. p-value for the confirmatory population when considering diastolic blood pressure.

    3.

    Study type

    cohort

    Study size

    733

    Association p-value

    = 0.028

    Allele frequency

    G=0.85

    Biogeographical group
    More info on groups

    East Asian

    Population description

    Study Cohort: Chinese Community-Based Comprehensive Prevention and Control of Hypertension project. p-value for the exploratory population when considering diastolic blood pressure.

    4.

    Study type

    cohort

    Study size

    1447

    Association p-value

    = 0.039

    Allele frequency

    G=0.86

    Biogeographical group
    More info on groups

    East Asian

    Population description

    Study Cohort: Chinese Community-Based Comprehensive Prevention and Control of Hypertension project. p-value for the total population when considering systolic blood pressure.

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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