Annotation of rs737866

Allele T is associated with decreased dose of morphine in people with Neoplasms as compared to allele C.

This was for alleviation of pain from cancer. The association was as part of a haplotype consisting of 11 rsIDs (the other rsIDs are rs2075507,rs7287550, rs5746849, rs740603, rs6269, rs2239393, rs4818, rs4680, rs174699, rs165728). The haplotype was associated with a dose reduction factor of 0.71 . Authors state that because the SNPs are linked, a strict Bonferroni correction is too conservative; however, that is what has been done here for p value. Also noted was that the carriers of haplotype 1 have had the cancer diagnosis longer than have carriers of other haplotypes, and so the true difference in morphine requirements may be even greater than observed here.

From Publication

Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain. Molecular pain. 2008. Rakvåg Trude T et al.
PMID:19094200(opens in new window) PMCID:PMC2644687(opens in new window) DOI:10.1186/1744-8069-4-64(opens in new window)

Gene

COMT

Variant

rs737866

Phenotype Category

Dosage, Efficacy

Association Significance

The study reports this association is significant

PharmGKB ID

981862160

Score
More info on scoring

0

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    197

    Association p-value

    = 0.055

    Allele frequency

    T=0.78

    Biogeographical group
    More info on groups

    European

    Population description

    Disease: cancer patients receiving oral morphine for pain. This cohort was also studied in PMID:15927391.

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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