Annotation of rs2242046

Genotype GG is not associated with increased response to gemcitabine in people with Carcinoma, Non-Small-Cell Lung as compared to genotypes AA + AG.

Response rate, median time to progression, and median survival time were not significantly different among patients with differing genotypes.

From Publication

Distribution of gemcitabine pathway genotypes in ethnic Asians and their association with outcome in non-small cell lung cancer patients. Lung cancer (Amsterdam, Netherlands). 2009. Soo Ross A et al.
PMID:18538445(opens in new window) DOI:10.1016/j.lungcan.2008.04.010(opens in new window)

Gene

SLC28A1

Variant

rs2242046

Phenotype Category

Efficacy

Association Significance

The study reports this association is not significant

PharmGKB ID

981785668

Score
More info on scoring

-1.25

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    retrospective

    Study size

    53

    Association p-value

    = 0.098

    Biogeographical group
    More info on groups

    Multiple groups, 43 subjects (81%) were Chinese and 10 (19%) were Malay

    Population description

    Disease: Patients with Non-Small Cell Lung Cancer taking gemcitabine.

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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