Annotation of rs7997012

Allele A is not associated with response to citalopram, fluoxetine or paroxetine in people with Depressive Disorder, Major as compared to allele G.

This SNP was also not found to be associated with Major Depressive Disorder.

Gene

HTR2A

Variant

rs7997012

Phenotype Category

Efficacy

Association Significance

The study reports this association is not significant

PharmGKB ID

981750801

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    case/control

    Study size

    481 (cases=86; controls=395)

    Biogeographical group
    More info on groups

    European

    Population description

    Disease: Major Depression. Remission:30 yes; 56 no. Responders: 51 yes;35 no.

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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