Annotation of rs2108622

Genotypes CT + TT are associated with increased dose of warfarin in people with mechanical heart valve replacement as compared to genotype CC.

3.2 mg/day vs. 2.9 mg/day. There were only 15 TT patients.

From Publication

CYP4F2 rs2108622: a minor significant genetic factor of warfarin dose in Han Chinese patients with mechanical heart valve replacement. British journal of clinical pharmacology. 2010. Cen Han-Jing et al.
PMID:20653676(opens in new window) PMCID:PMC2911553(opens in new window) DOI:10.1111/j.1365-2125.2010.03698.x(opens in new window)

Gene

CYP4F2

Variant

rs2108622

Phenotype Category

Dosage, Efficacy

Association Significance

The study reports this association is significant

PharmGKB ID

981483967

Score
More info on scoring

2

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    222

    Association p-value

    = 0.033

    Confidence interval

    0.2 - 1

    Allele frequency

    T=0.27

    Biogeographical group
    More info on groups

    East Asian

    Population description

    Study Cohort: MHVR patients from a Chinese Cardiovascular clinic.

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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