Annotation of rs2236225

Allele A is not associated with response to methotrexate in people with Arthritis, Rheumatoid.

This was considered a proxy SNP to compare with rs17850560 (MTHFD1:1958G>A) that has previously been shown to be involved in methotrexate efficacy.

From Publication

Genetic polymorphisms in key methotrexate pathway genes are associated with response to treatment in rheumatoid arthritis patients. The pharmacogenomics journal. 2013. Owen S A et al.
PMID:22450926(opens in new window) PMCID:PMC5604731(opens in new window) DOI:10.1038/tpj.2012.7(opens in new window)

Gene

MTHFD1

Variant

rs2236225

Phenotype Category

Efficacy

Association Significance

The study reports this association is not significant

PharmGKB ID

827863330

Score
More info on scoring

-1.75

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    309

    Biogeographical group
    More info on groups

    European

    Population description

    Drug: methotrexate monotherapy

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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