Annotation of rs9934438
Genotypes AG + GG are associated with increased dose of warfarin as compared to genotype AA.
with an international normalized ratio (INR) of 2.0-3.0. This SNP was in LD with rs7294 which was also significantly associated with warfarin-maintenance dose (but rs9934438 was chosen for further analysis).
From Publication
Genetic polymorphisms are associated with variations in warfarin maintenance dose in Han Chinese patients with venous thromboembolism. Pharmacogenomics. 2012. Zhang Wei et al.
Gene
Variant
Phenotype Category
Association Significance
PharmGKB ID
Score More info on scoring
Evidence for Clinical Annotations
This annotation has been used as evidence for the following clinical annotations.
Study Parameters
Study type
Study size
Association p-value
Allele frequency
Biogeographical group More info on groups
Population description
Study Cohort: Derivation cohort - stable patients with a constant warfarin dose with an INR of prothrombin time within the range of 2.0-3.0
Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.
History
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