Annotation of rs9934438

Genotypes AG + GG are associated with increased dose of warfarin as compared to genotype AA.

with an international normalized ratio (INR) of 2.0-3.0. This SNP was in LD with rs7294 which was also significantly associated with warfarin-maintenance dose (but rs9934438 was chosen for further analysis).

Gene

VKORC1

Variant

rs9934438

Phenotype Category

Dosage

Association Significance

The study reports this association is significant

PharmGKB ID

827845768

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    297

    Association p-value

    = 0.001

    Allele frequency

    G=0.076

    Biogeographical group
    More info on groups

    East Asian

    Population description

    Study Cohort: Derivation cohort - stable patients with a constant warfarin dose with an INR of prothrombin time within the range of 2.0-3.0

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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