Annotation of rs10871454

Allele T is associated with decreased dose of phenprocoumon maintenance dosage by 4.8 mg/week as compared to allele C.

Each additional VKORC1 variant allele reduced phenprocoumon maintenance dosage by 4.8 mg/week (P<0.0001) compared to wild type. The study found additive effects of the variant alleles of CYP2C9 (rs4086116) and CYP4F2 (rsrs2108622) on VKORC1.

Gene

STX4

Variant

rs10871454

Phenotype Category

Dosage

Association Significance

The study reports this association is significant

PharmGKB ID

827807849

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    244

    Association p-value

    < 1.0E-4

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

    No history available.