Annotation of rs10871454
Allele T is associated with decreased dose of phenprocoumon maintenance dosage by 4.8 mg/week as compared to allele C.
Each additional VKORC1 variant allele reduced phenprocoumon maintenance dosage by 4.8 mg/week (P<0.0001) compared to wild type. The study found additive effects of the variant alleles of CYP2C9 (rs4086116) and CYP4F2 (rsrs2108622) on VKORC1.
From Publication
Dependency of phenprocoumon dosage on polymorphisms in the VKORC1, CYP2C9, and CYP4F2 genes. Pharmacogenetics and genomics. 2011. Teichert Martina et al.
Gene
Variant
Phenotype Category
Association Significance
PharmGKB ID
Score More info on scoring
Evidence for Clinical Annotations
This annotation has been used as evidence for the following clinical annotations.
Study Parameters
Study type
Study size
Association p-value
Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.
History
No history available.