Annotation of rs2108622

Genotype CC is associated with decreased dose of warfarin as compared to genotype CT.

From Publication

Extending and evaluating a warfarin dosing algorithm that includes CYP4F2 and pooled rare variants of CYP2C9. Pharmacogenetics and genomics. 2010. Sagreiya Hersh et al.
PMID:20442691(opens in new window) PMCID:PMC3098751(opens in new window) DOI:10.1097/FPC.0b013e328338bac2(opens in new window)

Gene

CYP4F2

Variant

rs2108622

Phenotype Category

Dosage

Association Significance

The study reports this association is significant

PharmGKB ID

769246303

Score
More info on scoring

2

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

  1. Clinical Annotation for rs2108622 (CYP4F2); warfarin (level 1A Dosage)

Study Parameters

Study type

cohort

Study size

104

Association p-value

= 0.042

Biogeographical group
More info on groups

Multiple groups

Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

History

No history available.