Annotation of rs334558

Genotype GG is associated with increased response to citalopram and fluoxetine in people with Depressive Disorder, Major as compared to allele A.

From Publication

Glycogen synthase kinase-3beta gene is associated with antidepressant treatment response in Chinese major depressive disorder. The pharmacogenomics journal. 2008. Tsai S-J et al.
PMID:18195729(opens in new window) DOI:10.1038/sj.tpj.6500486(opens in new window)

Gene

GSK3B

Variant

rs334558

Phenotype Category

Efficacy

Association Significance

The study reports this association is significant

PharmGKB ID

769171579

Score
More info on scoring

2.5

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    168

    Association p-value

    = 0.002

    Biogeographical group
    More info on groups

    East Asian

    Population description

    Study Cohort: Chinese major depressive disorder patients

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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