Annotation of rs17731538

Genotype GG is associated with increased response to methotrexate in people with Psoriasis as compared to genotype AG.

From Publication

Genetic variation in efflux transporters influences outcome to methotrexate therapy in patients with psoriasis. The Journal of investigative dermatology. 2008. Warren Richard B et al.
PMID:18256692(opens in new window) DOI:10.1038/jid.2008.16(opens in new window)

Gene

ABCG2

Variant

rs17731538

Phenotype Category

Efficacy

Association Significance

The study reports this association is significant

PharmGKB ID

747991835

Score
More info on scoring

2.75

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    374

    Association p-value

    = 0.007

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

    No history available.