Annotation of rs8192935

Allele G is not associated with clearance of Dabigatran in healthy individuals as compared to allele A.

From Publication

Effect of Sex, Use of Pantoprazole and Polymorphisms in SLC22A1, ABCB1, CES1, CYP3A5 and CYP2D6 on the Pharmacokinetics and Safety of Dabigatran. Advances in therapy. 2020. Zubiaur Pablo et al.
PMID:32564268(opens in new window) DOI:10.1007/s12325-020-01414-x(opens in new window)

Gene

CES1

Variant

rs8192935

Phenotype Category

Metabolism/PK

Association Significance

The study reports this association is not significant

PharmGKB ID

1451207769

Score
More info on scoring

-0.75

Evidence for Clinical Annotations

This annotation has not been used as evidence for any clinical annotations.

Study Parameters

Study type

cohort

Study size

82

Allele frequency

A=0.384

Biogeographical group
More info on groups

Multiple groups, Caucasians and Latin Americans

Population description

men; women; healthy individuals

Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

History

No history available.