Annotation of CYP2B6*1, CYP2B6*5, CYP2B6*6, CYP2B6*7

CYP2B6 *6/*6 is not associated with concentrations of quetiapine as compared to CYP2B6 *1/*1 + *1/*5 + *1/*6 + *1/*7.

Study in patients receiving methadone maintenance therapy. No significant difference in plasma level-dose ratios of quetiapine between genotype groups. Patients were genotyped for the *4, *5, *6, *7 and *9 alleles, but no details on the specific variants assayed are given.

Gene

CYP2B6

Phenotype Category

Metabolism/PK

Association Significance

The study reports this association is not significant

PharmGKB ID

1451156368

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    14

    Biogeographical group
    More info on groups

    European

    Population description

    men; women

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

    No history available.