Annotation of CYP2B6*1, CYP2B6*5, CYP2B6*6, CYP2B6*7
CYP2B6 *6/*6 is not associated with concentrations of quetiapine as compared to CYP2B6 *1/*1 + *1/*5 + *1/*6 + *1/*7.
Study in patients receiving methadone maintenance therapy. No significant difference in plasma level-dose ratios of quetiapine between genotype groups. Patients were genotyped for the *4, *5, *6, *7 and *9 alleles, but no details on the specific variants assayed are given.
From Publication
Increased (R)-methadone plasma concentrations by quetiapine in cytochrome P450s and ABCB1 genotyped patients. Journal of clinical psychopharmacology. 2007. Uehlinger Claude et al.
Evidence for Clinical Annotations
This annotation has been used as evidence for the following clinical annotations.
Study Parameters
Study type
Study size
Biogeographical group More info on groups
Population description
men; women
Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.
History
No history available.