Annotation of rs6311

Allele T is not associated with response to escitalopram in people with Depression as compared to allele C.

From Publication

Association of BDNF, HTR2A, TPH1, SLC6A4, and COMT polymorphisms with tDCS and escitalopram efficacy: ancillary analysis of a double-blind, placebo-controlled trial. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). 2020. Brunoni Andre R et al.
PMID:31721892(opens in new window) PMCID:PMC7115450(opens in new window) DOI:10.1590/1516-4446-2019-0620(opens in new window)

Gene

HTR2A

Variant

rs6311

Phenotype Category

Efficacy

Association Significance

The study reports this association is not significant

PharmGKB ID

1451148566

Score
More info on scoring

-1.25

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

  1. Clinical Annotation for rs6311 (HTR2A); escitalopram; Depressive Disorder, Major (level 4 Efficacy)

Study Parameters

Study type

cohort

Study size

75

Association p-value

= 0.53

Biogeographical group
More info on groups

Multiple groups

Population description

men; women

Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

History

No history available.