Annotation of rs4680
Allele A is not associated with response to methadone in people with Opioid-Related Disorders as compared to allele G.
No significant difference in allele or genotype frequencies between responders and non-responders. Response was defined as "an absence of positive urine analysis, or at most, a one-time positive urine analysis for opioids during a 6-month follow-up period; nonconsumption of heroin or other types of opioid drugs according to participant self-reports; an absence of withdrawal symptoms; and a stable and regular attendance in the MMT therapeutic program". Note that the use of high-dose methadone was significantly lower in the non-responder group than in the responder group (p=0.01). This SNP was in high linkage disequilibirum with rs933271 and rs737866.
From Publication
Gene
Variant
Phenotype Category
Association Significance
PharmGKB ID
Score More info on scoring
Evidence for Clinical Annotations
This annotation has not been used as evidence for any clinical annotations.
Study Parameters
Study type
Study size
Association p-value
Statistical analysis
Confidence interval
Allele frequency
Biogeographical group More info on groups
Population description
Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.
History
No history available.