Annotation of rs4680

Allele A is not associated with response to methadone in people with Opioid-Related Disorders as compared to allele G.

No significant difference in allele or genotype frequencies between responders and non-responders. Response was defined as "an absence of positive urine analysis, or at most, a one-time positive urine analysis for opioids during a 6-month follow-up period; nonconsumption of heroin or other types of opioid drugs according to participant self-reports; an absence of withdrawal symptoms; and a stable and regular attendance in the MMT therapeutic program". Note that the use of high-dose methadone was significantly lower in the non-responder group than in the responder group (p=0.01). This SNP was in high linkage disequilibirum with rs933271 and rs737866.

Gene

COMT

Variant

rs4680

Phenotype Category

Efficacy

Association Significance

The study reports this association is not significant

PharmGKB ID

1451148020

Score
More info on scoring

-2

Evidence for Clinical Annotations

This annotation has not been used as evidence for any clinical annotations.

Study Parameters

Study type

cohort

Study size

820

Association p-value

= 0.73

Statistical analysis

OR: 0.94

Confidence interval

0.68 - 1.31

Allele frequency

A=0.243

Biogeographical group
More info on groups

East Asian

Population description

men; women

Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

History

No history available.