Annotation of rs1799971
Genotypes AG + GG are not associated with dose of oxycodone or sufentanil in people with Pain, Postoperative as compared to genotype AA.
No significant difference in total dosage of oxycodone or sufentanil between genotype groups.
From Publication
Correlation between gene polymorphism and opioid efficacy in patients with gastric or intestinal cancer. European review for medical and pharmacological sciences. 2019. Pu J et al.
Gene
Variant
Phenotype Category
Association Significance
PharmGKB ID
Score More info on scoring
Evidence for Clinical Annotations
This annotation has been used as evidence for the following clinical annotations.
Study Parameters
Study type
Study size
Association p-value
Allele frequency
Biogeographical group More info on groups
Population description
men; women
Drug: 30 patients were treated with oxycodone, 29 were treated with sufentanil
Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.
History
No history available.