Annotation of rs9934438

Genotypes AA + AG are associated with decreased dose of warfarin as compared to genotype GG.

From Publication

The effect of genetic and nongenetic factors on warfarin dose variability in Qatari population. The pharmacogenomics journal. 2020. Bader Loulia et al.
PMID:31653973(opens in new window) DOI:10.1038/s41397-019-0116-y(opens in new window)

Gene

VKORC1

Variant

rs9934438

Phenotype Category

Dosage

Association Significance

The study reports this association is significant

PharmGKB ID

1451130683

Score
More info on scoring

2.5

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

  1. Clinical Annotation for rs9934438 (VKORC1); warfarin (level 1B Dosage)

Study Parameters

Study type

cohort

Study size

149

Association p-value

< 0.0001

Biogeographical group
More info on groups

Near Eastern

Population description

men; women

Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

History

No history available.