Annotation of rs901865

Genotype CC is associated with increased severity of sedation due to desloratadine in people with Urticaria as compared to genotypes CT + TT.

Paper states that patients with the CC genotype experienced an increased severity of sedation compared to the CT genotype. However, according to Table 2, the CC genotype is more frequent in patients who did not experience sedation, while the CT genotype is more frequent in patients with sedation. A request for clarification has been sent to the corresponding authors. Please note that alleles have been complemented to the positive strand.

From Publication

Human H1 receptor (HRH1) gene polymorphism is associated with the severity of side effects after desloratadine treatment in Chinese patients with chronic spontaneous uticaria. The pharmacogenomics journal. 2020. Li Juan et al.
PMID:31406237(opens in new window) DOI:10.1038/s41397-019-0094-0(opens in new window)

Gene

HRH1

Variant

rs901865

Phenotype Category

Toxicity

Association Significance

The study reports this association is significant

PharmGKB ID

1451127020

Score
More info on scoring

3

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

  1. Clinical Annotation for rs901865 (HRH1); desloratadine; sedation and Urticaria (level 3 Toxicity)

Study Parameters

Study type

case/control

Study size

114 (cases=20; controls=94)

Association p-value

= 0.008

Statistical analysis

OR: 5.08

Confidence interval

1.62 - 16.12

Allele frequency

C: case=0.8158, control=0.9415

Population description

men; women

Study Cohort: Cases = Patients with desloratidine-induced sedation Controls = Patients with no sedation side effects

Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

History

No history available.