Annotation of rs2306283

Allele G is not associated with exposure to lopinavir or ritonavir in children with HIV Infections as compared to allele A.

No association between this variant and AUC0-12 of lopinavir or ritonavir in patients treated with lopinavir/ritonavir. Variant referred to in the paper as A388G.

Gene

SLCO1B1

Variant

rs2306283

Phenotype Category

Metabolism/PK

Association Significance

The study reports this association is not significant

Specialty Population

PediatricLearn more about pediatric tags(opens in new window)

PharmGKB ID

1451114883

Score
More info on scoring

-0.5

Evidence for Clinical Annotations

This annotation has not been used as evidence for any clinical annotations.

Study Parameters

Study type

cohort

Study size

50

Allele frequency

A=0.298

Biogeographical group
More info on groups

Multiple groups, Majority of patients were African American, 3 patients of African origin, 1 Asian patient , 1 Caucasian patient and 2 Hispanic patients.

Population description

children (pediatrics)

Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

History

No history available.