Annotation of rs2306283
Allele G is not associated with exposure to lopinavir or ritonavir in children with HIV Infections as compared to allele A.
No association between this variant and AUC0-12 of lopinavir or ritonavir in patients treated with lopinavir/ritonavir. Variant referred to in the paper as A388G.
From Publication
CYP3A5, ABCB1, and SLCO1B1 polymorphisms and pharmacokinetics and virologic outcome of lopinavir/ritonavir in HIV-infected children. Therapeutic drug monitoring. 2011. Rakhmanina Natella Y et al.
Gene
Variant
Phenotype Category
Association Significance
Specialty Population
PharmGKB ID
Score More info on scoring
Evidence for Clinical Annotations
This annotation has not been used as evidence for any clinical annotations.
Study Parameters
Study type
Study size
Allele frequency
Biogeographical group More info on groups
Population description
children (pediatrics)
Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.
History
No history available.