Annotation of rs16918941

Allele A is not associated with response to naltrexone in people with Tobacco Use Disorder as compared to allele G.

No significant association between this variant and smoking quit rate when naltrexone was used as augmentation to nicotine patch therapy.

Gene

OPRK1

Variant

rs16918941

Phenotype Category

Efficacy

Association Significance

The study reports this association is not significant

PharmGKB ID

1451114014

Score
More info on scoring

-1.75

Evidence for Clinical Annotations

This annotation has not been used as evidence for any clinical annotations.

Study Parameters

Study type

cohort

Study size

280

Association p-value

= 0.88

Allele frequency

A=0.08

Biogeographical group
More info on groups

Multiple groups, Caucasian, African American and Other ethnicities.

Population description

men; women

Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

History

No history available.