Annotation of rs524731

Allele A is not associated with response to naltrexone in people with Tobacco Use Disorder as compared to allele C.

No significant association between this variant and smoking quit rate when naltrexone was used as augmentation to nicotine patch therapy.

From Publication

Lack of Association between Opioid-Receptor Genotypes and Smoking Cessation Outcomes in a Randomized, Controlled Naltrexone Trial. Alcohol and alcoholism (Oxford, Oxfordshire). 2019. Roche Daniel J O et al.
PMID:31206155(opens in new window) PMCID:PMC7963143(opens in new window) DOI:10.1093/alcalc/agz046(opens in new window)

Gene

OPRM1

Variant

rs524731

Phenotype Category

Efficacy

Association Significance

The study reports this association is not significant

PharmGKB ID

1451113819

Score
More info on scoring

-1.75

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    280

    Association p-value

    = 0.14

    Allele frequency

    A=0.18

    Biogeographical group
    More info on groups

    Multiple groups, Caucasian, African American and Other ethnicities.

    Population description

    men; women

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

    No history available.