Annotation of rs1042714

Genotype CC is associated with increased response to atenolol or metoprolol in people with Tachycardia as compared to genotypes CG + GG.

Patients with the CC genotype had a significantly greater decrease in heart rate than patients with the CG or GG genotypes. Note that this association was only significant in white patients.

Gene

ADRB2

Variant

rs1042714

Phenotype Category

Efficacy

Association Significance

The study reports this association is significant

PharmGKB ID

1451106720

Score
More info on scoring

1.75

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

  1. Clinical Annotation for rs1042714 (ADRB2); atenolol or metoprolol; Tachycardia (level 3 Efficacy)

Study Parameters

1.

Study type

meta-analysis, retrospective

Study size

1214

Association p-value

= 0.0003

Biogeographical group
More info on groups

European

Population description

men; women

Study Cohort: Allele frequency and p-value given for analysis in the INVEST cohort.

2.

Study type

retrospective

Study size

200

Association p-value

= 0.0007

Allele frequency

C=0.595

Biogeographical group
More info on groups

Unknown. White patients

Population description

men; women

Study Cohort: Allele frequency and p-value given for analysis in the PEAR-2 cohort.

3.

Study type

retrospective

Study size

459

Association p-value

= 0.01

Allele frequency

C=0.567

Biogeographical group
More info on groups

European

Population description

men; women

Study Cohort: Allele frequency and p-value given for analysis in white patients from the PEAR cohort.

4.

Study type

retrospective

Study size

555

Association p-value

= 0.23

Allele frequency

C=0.615

Biogeographical group
More info on groups

European

Population description

men; women

Study Cohort: Allele frequency and p-value given for analysis in the INVEST cohort.

Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

History

No history available.