Annotation of rs10046

Genotype AA is not associated with response to exemestane in women with Breast Neoplasms as compared to genotypes AG + GG.

Although patients with the AA genotype in combination with the rs4646 CC genotype showed a steeper decrease in serum estradiol concentrations following exemestane treatment, the authors note that this combination of genotypes was associated with a higher baseline level of serum estradiol and that the association between the genotypes and the rate of estradiol decrease lost significance following adjustment for baseline concentrations.

Gene

CYP19A1

Variant

rs10046

Phenotype Category

PD

Association Significance

The study reports this association is not significant

PharmGKB ID

1451101020

Score
More info on scoring

-1

Evidence for Clinical Annotations

This annotation has not been used as evidence for any clinical annotations.

Study Parameters

Study type

clinical trial

Study size

124

Allele frequency

G=0.45

Population description

women

Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

History

No history available.