Annotation of rs10046
Genotype AA is not associated with response to exemestane in women with Breast Neoplasms as compared to genotypes AG + GG.
Although patients with the AA genotype in combination with the rs4646 CC genotype showed a steeper decrease in serum estradiol concentrations following exemestane treatment, the authors note that this combination of genotypes was associated with a higher baseline level of serum estradiol and that the association between the genotypes and the rate of estradiol decrease lost significance following adjustment for baseline concentrations.
From Publication
Gene
Variant
Phenotype Category
Association Significance
PharmGKB ID
Score More info on scoring
Evidence for Clinical Annotations
This annotation has not been used as evidence for any clinical annotations.
Study Parameters
Study type
Study size
Allele frequency
Population description
Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.
History
No history available.