Annotation of rs2228230

Allele T is not associated with dose of imatinib in people with Gastrointestinal Stromal Tumors as compared to allele C.

No significant association between genotype and chance of requiring an imatinib dose reduction.

Gene

PDGFRA

Variant

rs2228230

Phenotype Category

Dosage

Association Significance

The study reports this association is not significant

PharmGKB ID

1450933489

Score
More info on scoring

-1.75

Evidence for Clinical Annotations

This annotation has not been used as evidence for any clinical annotations.

Study Parameters

1.

Study type

cohort

Study size

315

Association p-value

= 0.458

Allele frequency

T=0.175

Biogeographical group
More info on groups

Unknown. Patients from Dutch clinics

Population description

men; women

Study Cohort: P-value given for univariate analysis

2.

Study type

cohort

Study size

315

Association p-value

= 0.992

Statistical analysis

OR: 1

Confidence interval

0.43 - 2.34

Allele frequency

T=0.175

Biogeographical group
More info on groups

Unknown. Patients from Dutch clinics

Population description

men; women

Study Cohort: Statistics given for multivariate analysis comparing the CC and CT genotypes. P-values lower than 0.00139 were considered significant.

3.

Study type

cohort

Study size

315

Association p-value

= 0.999

Allele frequency

T=0.175

Biogeographical group
More info on groups

Unknown. Patients from Dutch clinics

Population description

men; women

Study Cohort: Statistics given for multivariate analysis comparing the CC and CT genotypes against the TT genotype. P-values lower than 0.00139 were considered significant.

Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

History

No history available.