Annotation of rs1042718

Genotype AC is associated with increased response to fentanyl in healthy individuals as compared to genotype CC.

Volunteers with the AC genotype had a tendency towards a reduced systolic blood pressure following administration of fentanyl. There was no association between this variant and heart rate or QTc. Variant referred to as C523A in the paper.

From Publication

Polymorphisms associated with fentanyl pharmacokinetics, pharmacodynamics and adverse effects. Basic & clinical pharmacology & toxicology. 2019. Saiz-Rodríguez Miriam et al.
PMID:30281924(opens in new window) DOI:10.1111/bcpt.13141(opens in new window)

Gene

ADRB2

Variant

rs1042718

Phenotype Category

PD

Association Significance

The study reports this association is not significant

PharmGKB ID

1450931709

Score
More info on scoring

0.125

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    35

    Association p-value

    = 0.055

    Allele frequency

    C=0.814

    Biogeographical group
    More info on groups

    Multiple groups, Volunteers of European or Latino ethnicity.

    Population description

    men; women; healthy individuals

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

    No history available.