Annotation of rs3743077

Allele T is not associated with exposure to nicotine in men as compared to allele C.

No significant association between this allele and status as a smoker or non-smoker.

From Publication

Association and cis-mQTL analysis of variants in CHRNA3-A5, CHRNA7, CHRNB2, and CHRNB4 in relation to nicotine dependence in a Chinese Han population. Translational psychiatry. 2018. Liu Qiang et al.
PMID:29666375(opens in new window) PMCID:PMC5904126(opens in new window) DOI:10.1038/s41398-018-0130-x(opens in new window)

Gene

CHRNA3

Variant

rs3743077

Phenotype Category

Other

Association Significance

The study reports this association is not significant

PharmGKB ID

1450930607

Score
More info on scoring

-1

Evidence for Clinical Annotations

This annotation has not been used as evidence for any clinical annotations.

Study Parameters

Study type

case/control

Study size

5055 (cases=2616; controls=2439)

Association p-value

= 0.200

Statistical analysis

OR: 1.1

Allele frequency

T=0.23

Biogeographical group
More info on groups

East Asian

Population description

men

Study Cohort: Uncorrected p-value given.

Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

History

No history available.