Annotation of rs9606186

Allele C is not associated with response to risperidone in people with Schizophrenia as compared to allele G.

Please note that alleles have been complemented to the positive strand.

From Publication

Combined study of genetic and epigenetic biomarker risperidone treatment efficacy in Chinese Han schizophrenia patients. Translational psychiatry. 2017. Shi Y et al.
PMID:28696411(opens in new window) PMCID:PMC5538123(opens in new window) DOI:10.1038/tp.2017.143(opens in new window)

Gene

COMT

Variant

rs9606186

Phenotype Category

Efficacy

Association Significance

The study reports this association is not significant

PharmGKB ID

1450928312

Score
More info on scoring

-1.75

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    1.

    Study type

    cohort

    Study size

    288

    Association p-value

    = 0.511

    Statistical analysis

    OR: 0.816

    Confidence interval

    0.615 - 1.081

    Allele frequency

    C: case=0.247, control=0.287

    Biogeographical group
    More info on groups

    East Asian

    Population description

    men; women

    Study Cohort: Meta-analysis of Shanghai and Henan cohorts. Allele frequency for responders is given in the 'cases' box, while allele frequency for non-responders is given in the 'controls' box. P-value is given following Bonferroni correction.

    2.

    Study type

    cohort

    Study size

    98

    Association p-value

    = 0.511

    Statistical analysis

    OR: 0.387

    Confidence interval

    0.164 - 0.91

    Allele frequency

    C: case=0.137, control=0.292

    Biogeographical group
    More info on groups

    East Asian

    Population description

    men; women

    Study Cohort: Analysis in Henan cohort only. Allele frequency for responders is given in the 'cases' box, while allele frequency for non-responders is given in the 'controls' box. P-value is given following Bonferroni correction.

    3.

    Study type

    cohort

    Study size

    190

    Association p-value

    = 1

    Statistical analysis

    OR: 0.869

    Confidence interval

    0.634 - 1.192

    Allele frequency

    C: case=0.258, control=0.285

    Biogeographical group
    More info on groups

    East Asian

    Population description

    men; women

    Study Cohort: Analysis in Shanghai cohort only. Allele frequency for responders is given in the 'cases' box, while allele frequency for non-responders is given in the 'controls' box. P-value is given following Bonferroni correction.

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

    No history available.