Annotation of rs1799971

Genotypes AG + GG are associated with increased dose of opioids in people with Pain, Postoperative as compared to genotype AA.

Patients carrying the G allele had significantly higher opioid consumption in the first 24 hours post-surgery compared to those with the AA genotype. This significance was lost in the 48-hour postoperative period.

From Publication

The impact of genetic variation on sensitivity to opioid analgesics in patients with postoperative pain: a systematic review and meta-analysis. Pain physician. 2015. Ren Zhen-Yu et al.
PMID:25794200(opens in new window)

Gene

OPRM1

Variant

rs1799971

Phenotype Category

Dosage

Association Significance

The study reports this association is significant

PharmGKB ID

1450823183

Score
More info on scoring

1.5

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    1.

    Study type

    meta-analysis

    Study size

    3114

    Association p-value

    < 0.00001

    Population description

    men; women

    Study Cohort: Analysis of opioid consumption in the 24-hour postoperative period.

    2.

    Study type

    meta-analysis

    Study size

    595

    Association p-value

    < 0.36

    Population description

    men; women

    Study Cohort: Analysis of opioid consumption in the 48-hour postoperative period.

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

    No history available.