Annotation of rs1799971

Genotypes AG + GG are associated with decreased dose of ethanol in women as compared to genotype AA.

Women who carried the G allele were significantly less likely to be alcohol consumers than other groups.

From Publication

Association between Opioid Receptor mu 1 (OPRM1) Gene Polymorphisms and Tobacco and Alcohol Consumption in a Spanish Population. Bosnian journal of basic medical sciences. 2015. Francès Francesc et al.
PMID:26042510(opens in new window) PMCID:PMC4469933(opens in new window) DOI:10.17305/bjbms.2015.243(opens in new window)

Gene

OPRM1

Variant

rs1799971

Phenotype Category

Dosage

Association Significance

The study reports this association is significant

PharmGKB ID

1450822078

Score
More info on scoring

2.25

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

  1. Clinical Annotation for rs1799971 (OPRM1); ethanol (level 3 Dosage)

Study Parameters

Study type

case/control

Study size

465 (cases=357; controls=108)

Association p-value

= 0.049

Statistical analysis

OR: 0.55

Confidence interval

0.304 - 0.998

Biogeographical group
More info on groups

European

Population description

women

Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

History

No history available.