Annotation of SLCO1B1*1, SLCO1B1*15

SLCO1B1 *15 is associated with increased exposure to pitavastatin in healthy individuals as compared to SLCO1B1 *1/*1.

From Publication

Impact of ABCC2, ABCG2 and SLCO1B1 polymorphisms on the pharmacokinetics of pitavastatin in humans. Drug metabolism and pharmacokinetics. 2013. Oh Eun Sil et al.
PMID:23007012(opens in new window) DOI:10.2133/dmpk.dmpk-12-rg-068(opens in new window)

Gene

SLCO1B1

Haplotype

SLCO1B1*1, SLCO1B1*15

Phenotype Category

Metabolism/PK

Association Significance

The study reports this association is significant

PharmGKB ID

1450814783

Score
More info on scoring

2

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

  1. Clinical Annotation for SLCO1B1*1, SLCO1B1*5, SLCO1B1*15, SLCO1B1*37; pitavastatin (level 1A Metabolism/PK)

Study Parameters

1.

Study type

cohort

Study size

45

Association p-value

= 0.0002

Biogeographical group
More info on groups

Unknown. Korean participants, ethnicities not given.

Population description

men; healthy individuals

Study Cohort: P-value given for differences in Cmax between genotype groups.

2.

Study type

cohort

Study size

45

Association p-value

= 0.002

Biogeographical group
More info on groups

Unknown. Korean participants, ethnicities not given.

Population description

men; healthy individuals

Study Cohort: P-value given for differences in AUClast between genotype groups.

3.

Study type

cohort

Study size

45

Association p-value

= 0.004

Biogeographical group
More info on groups

Unknown. Korean participants, ethnicities not given.

Population description

men; healthy individuals

Study Cohort: P-value given for differences in AUCinf between genotype groups.

4.

Study type

cohort

Study size

45

Association p-value

= 0.004

Biogeographical group
More info on groups

Unknown. Korean participants, ethnicities not given.

Population description

men; healthy individuals

Study Cohort: P-value given for differences in Cl/F between genotype groups.

5.

Study type

cohort

Study size

45

Association p-value

= 0.527

Biogeographical group
More info on groups

Unknown. Korean participants, ethnicities not given.

Population description

men; healthy individuals

Study Cohort: P-value given for differences in Tmax between genotype groups.

6.

Study type

cohort

Study size

45

Association p-value

= 0.929

Biogeographical group
More info on groups

Unknown. Korean participants, ethnicities not given.

Population description

men; healthy individuals

Study Cohort: P-value given for differences in half-life between genotype groups.

Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

History

No history available.