Annotation of rs4680

Genotype GG is not associated with response to modafinil in people with methamphetamine dependence as compared to allele A.

No significant association between this variant and Treatment Effectiveness Scores following modafinil treatment compared to placebo in Non-Hispanic Caucasian subjects.

Gene

COMT

Variant

rs4680

Phenotype Category

Efficacy

Association Significance

The study reports this association is not significant

PharmGKB ID

1450813969

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    35

    Association p-value

    > 0.01

    Biogeographical group
    More info on groups

    European

    Population description

    men; women

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

    No history available.