Annotation of rs5569

Genotypes AG + GG are associated with increased response to methylphenidate in children with Attention Deficit Disorder with Hyperactivity as compared to genotype AA.

Post hoc least significant difference comparisons suggested that subjects with both G/G and G/A genotypes showed greater symptom reductions (7.15 ± 4.25 and 6.94 ± 5.60) than those with A/A genotypes (2.13 ± 4.29) (p < .01). Response was measured using the ADHD RS-IV scale.

From Publication

Association of norepinephrine transporter gene with methylphenidate response. Journal of the American Academy of Child and Adolescent Psychiatry. 2004. Yang Li et al.
PMID:15322419(opens in new window) DOI:10.1097/01.chi.0000131134.63368.46(opens in new window)

Gene

SLC6A2

Variant

rs5569

Phenotype Category

Efficacy

Association Significance

The study reports this association is significant

Specialty Population

PediatricLearn more about pediatric tags(opens in new window)

PharmGKB ID

1450376330

Score
More info on scoring

2

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    45

    Association p-value

    < 0.01

    Biogeographical group
    More info on groups

    East Asian

    Population description

    Study Cohort: ADHD RS-IV hyperactive-implusive subscale

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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