Annotation of rs3746544

Allele G is not associated with response to methylphenidate in children with Attention Deficit Disorder with Hyperactivity as compared to allele T.

There were no significant genetic effects on ADHD symptoms as measured by the parent-teacher composite.

From Publication

Pharmacogenetics of methylphenidate response in preschoolers with ADHD. Journal of the American Academy of Child and Adolescent Psychiatry. 2006. McGOUGH James et al.
PMID:17023870(opens in new window) DOI:10.1097/01.chi.0000235083.40285.08(opens in new window)

Gene

SNAP25

Variant

rs3746544

Phenotype Category

Efficacy

Association Significance

The study reports this association is not significant

Specialty Population

PediatricLearn more about pediatric tags(opens in new window)

PharmGKB ID

1450372874

Score
More info on scoring

-1.25

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    80

    Association p-value

    > 0.05

    Biogeographical group
    More info on groups

    Multiple groups

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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