Annotation of rs1947274

Allele A is not associated with response to methylphenidate in children with Attention Deficit Disorder with Hyperactivity as compared to allele C.

From Publication

Pharmacogenetics predictors of methylphenidate efficacy in childhood ADHD. Molecular psychiatry. 2018. Myer N M et al.
PMID:29230023(opens in new window) PMCID:PMC7039663(opens in new window) DOI:10.1038/mp.2017.234(opens in new window)

Gene

ADGRL3

Variant

rs1947274

Phenotype Category

Efficacy

Association Significance

The study reports this association is not significant

Specialty Population

PediatricLearn more about pediatric tags(opens in new window)

PharmGKB ID

1450180328

Score
More info on scoring

-1

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    meta-analysis

    Study size

    709

    Association p-value

    = 0.70

    Statistical analysis

    OR: 0.95

    Confidence interval

    0.71 - 1.26

    Biogeographical group
    More info on groups

    Multiple groups

    Population description

    children (pediatrics)

    Study Cohort: based on 3 studies

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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