Annotation of rs12456693
Allele T is associated with increased response to clopidogrel in people with Coronary Artery Disease as compared to allele C.
This variant is associated with increased H4 concentration.
From Publication
Influences of an NR1I2 polymorphism on heterogeneous antiplatelet reactivity responses to clopidogrel and clinical outcomes in acute ischemic stroke patients. Acta pharmacologica Sinica. 2019. Chen Yi-Bei et al.
Gene
Variant
Phenotype Category
Association Significance
PharmGKB ID
Score More info on scoring
Evidence for Clinical Annotations
This annotation has been used as evidence for the following clinical annotations.
Study Parameters
Study type
Study size
Association p-value
Biogeographical group More info on groups
Population description
Study Cohort: Chinese patients with coronary heart disease
Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.
History
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