Annotation of rs7621975

Allele A is not associated with dose of opioids in people with Pain as compared to allele G.

Variant had no significant association with opioid dose in either the development sample or the validation sample.

From Publication

Influence from genetic variability on opioid use for cancer pain: a European genetic association study of 2294 cancer pain patients. Pain. 2011. Klepstad P et al.
PMID:21398039(opens in new window) DOI:10.1016/j.pain.2011.01.040(opens in new window)

Gene

HTR3D

Variant

rs7621975

Phenotype Category

Dosage

Association Significance

The study reports this association is not significant

PharmGKB ID

1449714428

Score
More info on scoring

-2

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    1.

    Study type

    cohort

    Study size

    1475

    Association p-value

    = 0.530

    Allele frequency

    A=0.176

    Biogeographical group
    More info on groups

    European

    Population description

    men; women

    Study Cohort: All participants were taking opioids to treat moderate to severe pain. Statistics given for analysis with the development sample.

    2.

    Study type

    cohort

    Study size

    726

    Association p-value

    = 0.910

    Allele frequency

    A=0.176

    Biogeographical group
    More info on groups

    European

    Population description

    men; women

    Study Cohort: All participants were taking opioids to treat moderate to severe pain. Statistics given for analysis with the validation sample.

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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