Annotation of rs1127354

Genotype CC is not associated with dose of mercaptopurine or methotrexate in children with Precursor Cell Lymphoblastic Leukemia-Lymphoma as compared to genotype AC.

From Publication

SLCO1B1 Polymorphisms are Associated With Drug Intolerance in Childhood Leukemia Maintenance Therapy. Journal of pediatric hematology/oncology. 2018. Eldem İrem et al.
PMID:29683944(opens in new window) DOI:10.1097/MPH.0000000000001153(opens in new window)

Gene

ITPA

Variant

rs1127354

Phenotype Category

Dosage

Association Significance

The study reports this association is not significant

Specialty Population

PediatricLearn more about pediatric tags(opens in new window)

PharmGKB ID

1449311101

Score
More info on scoring

-0.25

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    1.

    Study type

    cohort

    Study size

    48

    Association p-value

    = 0.649

    Biogeographical group
    More info on groups

    Near Eastern

    Population description

    children (pediatrics)

    Drug: Methotrexate

    2.

    Study type

    cohort

    Study size

    48

    Association p-value

    = 0.894

    Allele frequency

    A=0.03; C=0.97

    Biogeographical group
    More info on groups

    Near Eastern

    Population description

    children (pediatrics)

    Drug: Mercaptopurine

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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