Annotation of rs6046

Allele A is not associated with dose of warfarin as compared to allele G.

From Publication

Warfarin Dose Model for the Prediction of Stable Maintenance Dose in Indian Patients. Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. 2018. Gaikwad Tejasvita et al.
PMID:28049362(opens in new window) PMCID:PMC6714673(opens in new window) DOI:10.1177/1076029616683046(opens in new window)

Gene

F7

Variant

rs6046

Phenotype Category

Dosage

Association Significance

The study reports this association is not significant

PharmGKB ID

1449251734

Score
More info on scoring

-1.75

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    300

    Association p-value

    = 0.881

    Allele frequency

    A=0.24; G=0.76

    Biogeographical group
    More info on groups

    Central/South Asian

    Population description

    Drug: Warfarin

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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