Annotation of rs510769
Allele T is associated with increased concentrations of cotinine in people with Heroin Dependence as compared to allele C.
Please note that alleles have been complemented to the positive strand
From Publication
OPRM1 genetic polymorphisms are associated with the plasma nicotine metabolite cotinine concentration in methadone maintenance patients: a cross sectional study. Journal of human genetics. 2013. Chen Yu-Ting et al.
Gene
Variant
Phenotype Category
Association Significance
PharmGKB ID
Score More info on scoring
Evidence for Clinical Annotations
This annotation has been used as evidence for the following clinical annotations.
Study Parameters
Study type
Study size
Association p-value
Allele frequency
Biogeographical group More info on groups
Population description
Study Cohort: Participants were receiving methadone maintenance therapy to treat heroin dependence.
Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.
History
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