Annotation of rs510769

Allele T is associated with increased concentrations of cotinine in people with Heroin Dependence as compared to allele C.

Please note that alleles have been complemented to the positive strand

Gene

OPRM1

Variant

rs510769

Phenotype Category

Metabolism/PK

Association Significance

The study reports this association is significant

PharmGKB ID

1449188382

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort

    Study size

    366

    Association p-value

    = 0.001

    Allele frequency

    T=0.168

    Biogeographical group
    More info on groups

    East Asian

    Population description

    Study Cohort: Participants were receiving methadone maintenance therapy to treat heroin dependence.

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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