Annotation of rs1799972

Allele T is not associated with dose of morphine in people with Pain as compared to allele C.

No association was observed between this variant and a patient's initial dose requirement or their need to escalate their dose of morphine.

From Publication

Genetic Analysis of Mu and Kappa Opioid Receptor and COMT Enzyme in Cancer Pain Tunisian Patients Under Opioid Treatment. Iranian journal of public health. 2017. Chatti Imen et al.
PMID:29259946(opens in new window) PMCID:PMC5734971(opens in new window)

Gene

OPRM1

Variant

rs1799972

Phenotype Category

Dosage, Efficacy

Association Significance

The study reports this association is not significant

PharmGKB ID

1449182334

Score
More info on scoring

-1.5

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    cohort, prospective

    Study size

    129

    Association p-value

    = 0.3441

    Statistical analysis

    OR: 0.44

    Confidence interval

    0.08 - 2.55

    Allele frequency

    T=0.027

    Biogeographical group
    More info on groups

    Near Eastern

    Population description

    Study Cohort: All participants were cancer patients receiving morphine to control cancer pain.

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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