Annotation of rs17724494

Allele C is associated with decreased response to duloxetine in people with Depressive Disorder, Major as compared to allele T.

Variant was suggestively significant, but did not reach genome-wide significance. Variant was associated with an decreased likelihood of the patient entering remission, as defined by a score of 10 or more on the Montgomery-Asberg Depression Rating Scale (MADRS) score at the end of treatment.

From Publication

GWAS-based machine learning approach to predict duloxetine response in major depressive disorder. Journal of psychiatric research. 2018. Maciukiewicz Malgorzata et al.
PMID:29407288(opens in new window) DOI:10.1016/j.jpsychires.2017.12.009(opens in new window)

Gene

ANO2

Variant

rs17724494

Phenotype Category

Efficacy

Association Significance

The study reports this association is significant

PharmGKB ID

1449168205

Score
More info on scoring

0

Evidence for Clinical Annotations

This annotation has been used as evidence for the following clinical annotations.

    Study Parameters

    Study type

    GWAS

    Study size

    186

    Association p-value

    < 5E-5

    Statistical analysis

    OR: 0.18

    Biogeographical group
    More info on groups

    European

    Population description

    men; women

    Study Cohort: Individuals had been enrolled in clinical trials where they had received duloxetine for up to eight weeks.

    Note: Alleles in PharmGKB are mapped to the positive chromosomal strand. Therefore, variants in genes on the "minus" strand (eg. VKORC1) are complemented in PharmGKB annotations.

    History

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